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1

Tobacco Heating System 2.2 has a limited impact on DNA methylation of candidate enhancers in mouse lung compared with cigarette smoke

Choukrallah, Mohamed-Amin, Sierro, Nicolas, Martin, Florian, Baumer, Karine, Thomas, Jerome, Ouadi, Sonia, Hoeng, Julia, Peitsch, Manuel C., Ivanov, Nikolai V.

Journal:

Food and Chemical Toxicology

Année:

2019

Langue:

english

Fichier:

PDF, 2.17 MB

english, 2019

2

A meta-analysis of microRNAs expressed in human aerodigestive epithelial cultures and their role as potential biomarkers of exposure response to nicotine-containing products

Sewer, Alain, Zanetti, Filippo, Iskandar, Anita R., Guedj, Emmanuel, Dulize, Remi, Peric, Dariusz, Bornand, David, Mathis, Carole, Martin, Florian, Ivanov, Nikolai V., Peitsch, Manuel C., Hoeng, Julia

Journal:

Toxicology Reports

Année:

2020

Fichier:

PDF, 9.52 MB

2020

3

[Methods in Pharmacology and Toxicology] Computational Systems Toxicology ||

Hoeng, Julia, Peitsch, Manuel C.

Année:

2015

Langue:

english

Fichier:

PDF, 19.22 MB

english, 2015

4

Training and evaluation corpora for the extraction of causal relationships encoded in biological expression language (BEL)

Fluck, Juliane, Madan, Sumit, Ansari, Sam, Kodamullil, Alpha T., Karki, Reagon, Rastegar-Mojarad, Majid, Catlett, Natalie L., Hayes, William, Szostak, Justyna, Hoeng, Julia, Peitsch, Manuel

Journal:

Année:

2016

Langue:

english

Fichier:

PDF, 698 KB

english, 2016

5

Verification of systems biology research in the age of collaborative competition

Meyer, Pablo, Alexopoulos, Leonidas G, Bonk, Thomas, Califano, Andrea, Cho, Carolyn R, de la Fuente, Alberto, de Graaf, David, Hartemink, Alexander J, Hoeng, Julia, Ivanov, Nikolai V, Koeppl, Heinz, L

Journal:

Nature Biotechnology

Année:

2011

Langue:

english

Fichier:

PDF, 492 KB

english, 2011

6

The BEL information extraction workflow (BELIEF): evaluation in the BioCreative V BEL and IAT track

Madan, Sumit, Hodapp, Sven, Senger, Philipp, Ansari, Sam, Szostak, Justyna, Hoeng, Julia, Peitsch, Manuel, Fluck, Juliane

Journal:

Année:

2016

Langue:

english

Fichier:

PDF, 943 KB

english, 2016

7

Physiological and biological characterization of smokers with and without COPD

Chaudhary, Nveed, Luettich, Karsta, Peck, Michael J., Pierri, Elena, Felber-Medlin, Loyse, Vuillaume, Gregory, Leroy, Patrice, Hoeng, Julia, Peitsch, Manuel C.

Journal:

Année:

2018

Langue:

english

Fichier:

PDF, 1.10 MB

english, 2018

8

Antiparasitic properties of leaf extracts derived from selected Nicotiana species and Nicotiana tabacum varieties

Schorderet Weber, Sandra, Kaminski, Kacper P., Perret, Jean-Luc, Leroy, Patrice, Mazurov, Anatoly, Peitsch, Manuel C., Ivanov, Nikolai V., Hoeng, Julia

Journal:

Food and Chemical Toxicology

Année:

2019

Langue:

english

Fichier:

PDF, 1.26 MB

english, 2019

9

The extraction of complex relationships and their conversion to biological expression language (BEL) overview of the BioCreative VI (2017) BEL track

Madan, Sumit, Szostak, Justyna, Komandur Elayavilli, Ravikumar, Tsai, Richard Tzong-Han, Ali, Mehdi, Qian, Longhua, Rastegar-Mojarad, Majid, Hoeng, Julia, Fluck, Juliane

Journal:

Année:

2019

Langue:

english

Fichier:

PDF, 2.07 MB

english, 2019

10

Analysis of chemical deposits on tooth enamel exposed to total particulate matter from cigarette smoke and tobacco heating system 2.2 aerosol by novel GCâMS deconvolution procedures

Haiduc, Adrian, Zanetti, Filippo, Zhao, Xiaoyi, Schlage, Walter K., Scherer, Max, Pluym, Nikola, Schlenger, Patrick, Ivanov, Nikolai V., Majeed, Shoaib, Hoeng, Julia, Peitsch, Manuel C., Ren, Yanfang,

Journal:

Journal of Chromatography B

Année:

2020

Fichier:

PDF, 3.02 MB

2020

11

A network-based approach to quantifying the impact of biologically active substances

Julia Hoeng, Renée Deehan, Dexter Pratt, Florian Martin, Alain Sewer, Ty M. Thomson, David A. Drubin, Christina A. Waters, David de Graaf, Manuel C. Peitsch

Journal:

Drug Discovery Today

Année:

2012

Langue:

english

Fichier:

PDF, 978 KB

english, 2012

12

Smoker bronchial epithelium: A multi-dimensional in vivo/in vitro comparison

Carole Mathis, Carine Poussin, Dirk Weisensee, Stephan Gebel, Vincenzo Belcastro, Yang Xiang, Alain Sewer, Arnd Hengstermann, Sam Ansari, Sandra Wagner, Julia Hoeng, Manuel Peitsch

Journal:

Toxicology Letters

Année:

2012

Langue:

english

Fichier:

PDF, 86 KB

english, 2012

13

Assessment of network perturbation amplitudes by applying high-throughput data to causal biological networks

Florian Martin, Ty M Thomson, Alain Sewer, David A Drubin, Carole Mathis, Dirk Weisensee, Dexter Pratt, Julia Hoeng, Manuel C Peitsch

Journal:

BMC Systems Biology

Année:

2012

Langue:

english

Fichier:

PDF, 571 KB

english, 2012

14

Systems Toxicology: From Basic Research to Risk Assessment

Sturla, Shana J., Boobis, Alan R., FitzGerald, Rex E., Hoeng, Julia, Kavlock, Robert J., Schirmer, Kristin, Whelan, Maurice, Wilks, Martin F., Peitsch, Manuel C.

Journal:

Chemical Research in Toxicology

Année:

2014

Langue:

english

Fichier:

PDF, 4.17 MB

english, 2014

15

Case study: the role of mechanistic network models in systems toxicology

Hoeng, Julia, Talikka, Marja, Martin, Florian, Sewer, Alain, Yang, Xiang, Iskandar, Anita, Schlage, Walter K., Peitsch, Manuel C.

Journal:

Drug Discovery Today

Année:

2014

Langue:

english

Fichier:

PDF, 3.50 MB

english, 2014

16

A 28-day rat inhalation study with an integrated molecular toxicology endpoint demonstrates reduced exposure effects for a prototypic modified risk tobacco product compared with conventional cigarettes

Kogel, Ulrike, Schlage, Walter K., Martin, Florian, Xiang, Yang, Ansari, Sam, Leroy, Patrice, Vanscheeuwijck, Patrick, Gebel, Stephan, Buettner, Ansgar, Wyss, Christoph, Esposito, Marco, Hoeng, Julia,

Journal:

Food and Chemical Toxicology

Année:

2014

Langue:

english

Fichier:

PDF, 2.73 MB

english, 2014

17

Corrigendum to “Identification of New Human Cadherin Genes Using a Combination of Protein Motif Search and Gene Finding Methods” [J. Mol. Biol. 337 (2004) 307–317]

Hoeng, Julia C., Ivanov, Nikolai V., Hodor, Paul, Xia, Menghang, Wei, Nan, Blevins, Richard, Gerhold, David, Borodovsky, Mark, Liu, Yuan

Journal:

Journal of Molecular Biology

Année:

2014

Langue:

english

Fichier:

PDF, 169 KB

english, 2014

18

Systems biology approach reveals a dose-dependent recovery of primary human airway epithelium culture after exposure to cigarette smoke

Mathis, Carole, Gebel, Stephan, Poussin, Carine, Hengstermann, Arnd, Weisensee, Dirk, Sewer, Alain, Belcastro, Vincenzo, Ansari, Sam, Wagner, Sandra, Hoeng, Julia, Peitsch, Manuel C.

Journal:

Toxicology Letters

Année:

2013

Langue:

english

Fichier:

PDF, 72 KB

english, 2013

19

Mechanism of an indirect effect of aqueous cigarette smoke extract on the adhesion of monocytic cells to endothelial cells in an in vitro assay revealed by transcriptomics analysis

Poussin, Carine, Gallitz, Inka, Schlage, Walter K., Steffen, Yvonne, Stolle, Katrin, Lebrun, Stefan, Hoeng, Julia, Peitsch, Manual C., Lietz, Michael

Journal:

Toxicology in Vitro

Année:

2014

Langue:

english

Fichier:

PDF, 2.85 MB

english, 2014

20

Systems-toxicology approach to evaluate the biological impact of a subset of harmful/potentially harmful constituents of tobacco smoke

Gonzalez-Suarez, Ignacio, Mathis, Carole, Guedj, Emmanuel, Walker, Paul, Ellis, Samantha, Woodhouse, Heather, Dulize, Remi, Wagner, Sandra, Martin, Florian, Ivanov, Nikolai, Hoeng, Julia, Peitsch, Man

Journal:

Toxicology Letters

Année:

2013

Langue:

english

Fichier:

PDF, 73 KB

english, 2013

21

Quantification of biological network perturbations for mechanistic insight and diagnostics using two-layer causal models

Florian Martin,Alain Sewer,Marja Talikka,Yang Xiang,Julia Hoeng…

Journal:

BMC Bioinformatics

Année:

2014

Langue:

english

Fichier:

PDF, 2.27 MB

english, 2014

22

Reduced impact of a prototypic modified risk tobacco product compared with conventional cigarette smoke on exposed human and rat primary normal bronchial epithelial cells

Mathis, Carole, Messinis, Dimitris E., Kogel, Ulrike, Poussin, Carine, Frentzel, Stefan, Guedj, Emmanuel, Merg, Celine, Ivanov, Nikolai, Peitsch, Manuel C., Hoeng, Julia

Journal:

Toxicology Letters

Année:

2014

Langue:

english

Fichier:

PDF, 73 KB

english, 2014

23

Aqueous cigarette smoke extract promotes the adhesion of monocytic cells to human coronary artery endothelial cells in direct and indirect-dependent ways

Poussin, Carine, Laurent, Alexandra, Hoeng, Julia, Peitsch, Manuel C., De Leon, Hector

Journal:

Toxicology Letters

Année:

2014

Langue:

english

Fichier:

PDF, 67 KB

english, 2014

24

Proteomics for systems toxicology

Titz, Bjoern, Elamin, Ashraf, Martin, Florian, Schneider, Thomas, Dijon, Sophie, Ivanov, Nikolai V., Hoeng, Julia, Peitsch, Manuel C.

Journal:

Computational and Structural Biotechnology Journal

Année:

2014

Langue:

english

Fichier:

PDF, 1.48 MB

english, 2014

25

sbv IMPROVER Diagnostic Signature Challenge

Hoeng, Julia, Stolovitzky, Gustavo, Peitsch, Manuel C

Journal:

Systems Biomedicine

Année:

2013

Langue:

english

Fichier:

PDF, 171 KB

english, 2013

26

sbv IMPROVER Diagnostic Signature Challenge

Rhrissorrakrai, Kahn, Rice, J Jeremy, Boue, Stephanie, Talikka, Marja, Bilal, Erhan, Martin, Florian, Meyer, Pablo, Norel, Raquel, Xiang, Yang, Stolovitzky, Gustavo, Hoeng, Julia, Peitsch, Manuel C

Journal:

Systems Biomedicine

Année:

2013

Langue:

english

Fichier:

PDF, 1.15 MB

english, 2013

27

Characterization of the Vitrocell® 24/48in vitroaerosol exposure system using mainstream cigarette smoke

Majeed, Shoaib, Frentzel, Stefan, Wagner, Sandra, Kuehn, Diana, Leroy, Patrice, Guy, Philippe A, Knorr, Arno, Hoeng, Julia, Peitsch, Manuel C

Journal:

Chemistry Central Journal

Année:

2014

Langue:

english

Fichier:

PDF, 1.64 MB

english, 2014

28

On Crowd-verification of Biological Networks

Hoeng, Julia, Ansari, Sam, Kleiman, Robin, Binder, Jean, Hayes, William, Iskandar, Anita, Rhrissorrakrai, Kahn, Norel, Raquel, O'Neel, Bruce, Peitsch, Manuel, Poussin, Carine, Talikka, Marja, Schlage,

Journal:

Bioinformatics and Biology Insights

Année:

2013

Langue:

english

Fichier:

PDF, 4.99 MB

english, 2013

29

Discovery of Emphysema Relevant Molecular Networks from an A/J Mouse Inhalation Study Using Reverse Engineering and Forward Simulation (REFS™)

Xiang,, Kogel, Ulrike, Gebel, Stephan, Peck, Michael, Peitsch, Manuel, Akmaev, Viatcheslav, Hoeng, Julia

Journal:

Gene Regulation and Systems Biology

Année:

2014

Langue:

english

Fichier:

PDF, 1.68 MB

english, 2014

30

Systems Approaches Evaluating the Perturbation of Xenobiotic Metabolism in Response to Cigarette Smoke Exposure in Nasal and Bronchial Tissues

Iskandar, Anita R., Martin, Florian, Talikka, Marja, Schlage, Walter K., Kostadinova, Radina, Mathis, Carole, Hoeng, Julia, Peitsch, Manuel C.

Journal:

BioMed Research International

Année:

2013

Langue:

english

Fichier:

PDF, 5.75 MB

english, 2013

31

Systematic Verification of Upstream Regulators of a Computable Cellular Proliferation Network Model on Non-Diseased Lung Cells Using a Dedicated Dataset

Belcastro,, Poussin, Carine, Gebel, Stephan, Mathis, Carole, Lichtner, Rosemarie, Wagner, Sandra, Quadt-Humme, Sibille, Schlage, Walter, Hoeng, Julia, Peitsch, Manuel

Journal:

Bioinformatics and Biology Insights

Année:

2013

Langue:

english

Fichier:

PDF, 1.30 MB

english, 2013

32

Systems approaches to computational modeling of the oral microbiome

Dimitrov, Dimiter V., Hoeng, Julia

Journal:

Frontiers in Physiology

Année:

2013

Langue:

english

Fichier:

PDF, 1.33 MB

english, 2013

33

A prototypic modified risk tobacco product exhibits reduced effects on chemotaxis and transendothelial migration of monocytes compared with a reference cigarette

van der Toorn, Marco, Frentzel, Stefan, Goedertier, Didier, Peitsch, Manuel, Hoeng, Julia, De Leon, Hector

Journal:

Food and Chemical Toxicology

Année:

2015

Langue:

english

Fichier:

PDF, 2.50 MB

english, 2015

34

Impact Assessment of Cigarette Smoke Exposure on Organotypic Bronchial Epithelial Tissue Cultures: A Comparison of Mono-Culture and Coculture Model Containing Fibroblasts

Iskandar, Anita R., Xiang, Yang, Frentzel, Stefan, Talikka, Marja, Leroy, Patrice, Kuehn, Diana, Guedj, Emmanuel, Martin, Florian, Mathis, Carole, Ivanov, Nikolai V., Peitsch, Manuel C., Hoeng, Julia

Journal:

Toxicological Sciences

Année:

2015

Langue:

english

Fichier:

PDF, 1.52 MB

english, 2015

35

[Methods in Pharmacology and Toxicology] Computational Systems Toxicology || Aerosol Dosimetry Modeling Using Computational Fluid Dynamics

Hoeng, Julia, Peitsch, Manuel C.

Année:

2015

Langue:

english

Fichier:

PDF, 574 KB

english, 2015

36

[Methods in Pharmacology and Toxicology] Computational Systems Toxicology || Xenobiotic Metabolism Activation as a Biomarker of Cigarette Smoke Exposure Response

Hoeng, Julia, Peitsch, Manuel C.

Année:

2015

Langue:

english

Fichier:

PDF, 1.54 MB

english, 2015

37

[Methods in Pharmacology and Toxicology] Computational Systems Toxicology || High-Content Screening: Understanding and Managing Mechanistic Data to Better Predict Toxicity

Hoeng, Julia, Peitsch, Manuel C.

Année:

2015

Langue:

english

Fichier:

PDF, 922 KB

english, 2015

38

[Methods in Pharmacology and Toxicology] Computational Systems Toxicology || Causal Biological Network Database: A Comprehensive Platform of Causal Biological Network Models Focused on the Pulmonary and Vascular Systems

Hoeng, Julia, Peitsch, Manuel C.

Année:

2015

Langue:

english

Fichier:

PDF, 1.83 MB

english, 2015

39

Systems Biology Reveals Cigarette Smoke-Induced Concentration-Dependent Direct and Indirect Mechanisms That Promote Monocyte–Endothelial Cell Adhesion

Poussin, Carine, Laurent, Alexandra, Peitsch, Manuel C., Hoeng, Julia, De Leon, Hector

Journal:

Toxicological Sciences

Année:

2015

Langue:

english

Fichier:

PDF, 1.24 MB

english, 2015

40

Systems toxicology-based assessment of the candidate modified risk tobacco product THS2.2 for the adhesion of monocytic cells to human coronary arterial endothelial cells

Poussin, Carine, Laurent, Alexandra, Peitsch, Manuel C., Hoeng, Julia, De Leon, Hector

Journal:

Année:

2016

Langue:

english

Fichier:

PDF, 3.54 MB

english, 2016

41

The Apoe−/− mouse model: a suitable model to study cardiovascular and respiratory diseases in the context of cigarette smoke exposure and harm reduction

Lo Sasso, Giuseppe, Schlage, Walter K., Boué, Stéphanie, Veljkovic, Emilija, Peitsch, Manuel C., Hoeng, Julia

Journal:

Journal of Translational Medicine

Année:

2016

Langue:

english

Fichier:

PDF, 2.27 MB

english, 2016

42

[WORLD SCIENTIFIC Proceedings of the Pacific Symposium - Kohala Coast, Hawaii, USA (4 – 8 January 2015)] Biocomputing 2015 - REPUTATION-BASED COLLABORATIVE NETWORK BIOLOGY

BINDER, JEAN, BOUE, STEPHANIE, DI FABIO, ANSELMO, FIELDS, R. BRETT, HAYES, WILLIAM, HOENG, JULIA, PARK, JENNIFER S., PEITSCH, MANUEL C.

Langue:

english

Fichier:

PDF, 1.24 MB

english

43

Aerosol Flow in the Vitrocell 24/48 Exposure System: Flow Mixing and Aerosol Coalescence

Kuczaj, Arkadiusz K., Nordlund, Markus, Jayaraju, Santhosh, Komen, Ed, Krebs, Tobias, Peitsch, Manuel C., Hoeng, Julia

Journal:

Applied In Vitro Toxicology

Année:

2016

Langue:

english

Fichier:

PDF, 788 KB

english, 2016

44

Evaluation of the Tobacco Heating System 2.2. Part 1: Description of the system and the scientific assessment program

Smith, Maurice R., Clark, Bruce, Lüdicke, Frank, Schaller, Jean-Pierre, Vanscheeuwijck, Patrick, Hoeng, Julia, Peitsch, Manuel C.

Journal:

Regulatory Toxicology and Pharmacology

Année:

2016

Langue:

english

Fichier:

PDF, 1.12 MB

english, 2016

45

A new fluorescence-based method for characterizing in vitro aerosol exposure systems

Steiner, Sandro, Majeed, Shoaib, Kratzer, Gilles, Hoeng, Julia, Frentzel, Stefan

Journal:

Toxicology in Vitro

Année:

2016

Langue:

english

Fichier:

PDF, 905 KB

english, 2016

46

Evaluation of the tobacco heating system 2.2. Part 9: Application of systems pharmacology to identify exposure response markers in peripheral blood of smokers switching to THS2.2

Martin, Florian, Talikka, Marja, Ivanov, Nikolai V., Haziza, Christelle, Hoeng, Julia, Peitsch, Manuel C.

Journal:

Regulatory Toxicology and Pharmacology

Année:

2016

Langue:

english

Fichier:

PDF, 3.63 MB

english, 2016

47

From Transcriptomics to Predictive Toxicology

Poussin, Carine, Belcastro, Vincenzo, Hoeng, Julia

Journal:

Année:

2016

Langue:

english

Fichier:

PDF, 129 KB

english, 2016

48

Evaluation of the Tobacco Heating System 2.2 (THS2.2). Part 5: microRNA expression from a 90-day rat inhalation study indicates that exposure to THS2.2 aerosol causes reduced effects on lung tissue compared with cigarette smoke

Sewer, Alain, Kogel, Ulrike, Talikka, Marja, Wong, Ee Tsin, Martin, Florian, Xiang, Yang, Guedj, Emmanuel, Ivanov, Nikolai V., Hoeng, Julia, Peitsch, Manuel C.

Journal:

Regulatory Toxicology and Pharmacology

Année:

2016

Langue:

english

Fichier:

PDF, 2.20 MB

english, 2016

49

Evaluation of the Tobacco Heating System 2.2. Part 4: 90-day OECD 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects compared with cigarette smoke

Wong, Ee Tsin, Kogel, Ulrike, Veljkovic, Emilija, Martin, Florian, Xiang, Yang, Boue, Stephanie, Vuillaume, Gregory, Leroy, Patrice, Guedj, Emmanuel, Rodrigo, Gregory, Ivanov, Nikolai V., Hoeng, Julia

Journal:

Regulatory Toxicology and Pharmacology

Année:

2016

Langue:

english

Fichier:

PDF, 1.23 MB

english, 2016

50

Aerosol from Tobacco Heating System 2.2 has reduced impact on mouse heart gene expression compared with cigarette smoke

Szostak, Justyna, Boué, Stéphanie, Talikka, Marja, Guedj, Emmanuel, Martin, Florian, Phillips, Blaine, Ivanov, Nikolai V., Peitsch, Manuel C., Hoeng, Julia

Journal:

Food and Chemical Toxicology

Année:

2017

Langue:

english

Fichier:

PDF, 2.86 MB

english, 2017